Split from this thread.
I'm having this problem also where whenever I click a link in an email in Outlook 2016, I get "Something unexpected went wrong with URL...." I don't think the problem is in Outlook because I get the same problem in the Thunderbird email client also, although in the Windows Mail email app, I don't encounter the problem. I've tried resetting the default apps by click the Reset button in the Settings/Default Apps section of Windows 10, but that didn't resolve the problem. The default browser is set to Microsoft Edge and default email is set to Microsoft Outlook 2016. I've run a PC Optimizer to detect any potential problems in the registry, I've scanned my PC for viruses, I've reinstalled Office 365 several times, but nothing I've done has resolved the problem. Any ideas?